Metabolism of I-pyrrolidone Carboxylic Acid and Its Stability to Acids and Alkalies.*
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چکیده
In the study of the physiology of the amino-acids and their derivatives the cyclic compounds always engage attention because presumably the formation or disruption of ring structures requires special processes. No doubt there is considerable reason for assuming that such should be the case with homocyclic structures where there is union of carbon with carbon, but then evidence has been accumulated that the formation or oxidation of chain compounds is likewise not a simple matter.’ Among the ring compounds considerable attention has been devoted to the metabolism of the pyrrole nucleus primarily through its participation in the structure of the pigments chlorophyll and hemoglobin as the alkylated pyrroles and in simple proteins where it occurs as proline, oxyproline, and forms part of the complex tryptophane and oxytryptophane nuclei. Abderhalden has repeatedly called attention to the possibility of proline being a limiting factor in the growth processes of animals when not present in the amino-acid mixture of the proteins ingested. He has attempted to determine if the addition of proline to a proline-free ration would be able to restore growth in animals in which growth had been inhibited by feeding aminoacid mixtures as the source of protein, but invariably has me6 with failure. Apparently, part of the difficulty is due to the fact that proline is very easily decomposed, for even concentrat-
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